The vasculature permeates nearly every tissue in the human body, facilitating gas and nutrient exchange, supporting tissue homeostasis, regulating immune responses, and performing organ-specific functions. However, the molecular characteristics of vascular cell populations across different organs and tissues remain poorly understood.

To address this, we conducted single-cell RNA sequencing (scRNA-seq) across 19 human organs and tissues, integrating data from 66,623 vascular cells obtained from 62 donors. This analysis enabled us to construct a comprehensive vascular atlas, revealing 42 distinct endothelial and mural cell states, each defined by unique vessel and organ-specific gene expression profiles.

The gene signatures of these populations, and their cellular interactions, can be explored interactively below. The scRNA-seq object and Visium spatial transcriptomics data used in our publication are also available for download.